Glomerular Permeability Is Altered by Loss of P0, a Myelin Protein Expressed in Glomerular Epithelial Cells
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چکیده
منابع مشابه
Glomerular Epithelial Cells Produce
EndothelinI , a vasoactive peptide originally isolated from vascular endothelial cell culture supernatants, has constricting or mitogenic effects on smooth muscle and glomerular mesangial cells. Whether or not cultured rat glomerular epithelial cells synthesize endothelin-1 was assessed. Under basal culture conditions, the synthesis and release of endothelin-1 peptide by glomerular epithelial c...
متن کاملGlomerular epithelial cells secrete a glomerular basement membrane-degrading metalloproteinase.
Cultured rat glomerular epithelial cells (GEC) were examined for their ability to release extracellular matrix-degrading proteinases with [3H]gelatin as substrate. GEC-conditioned media, under serum-free conditions, contained modest amounts of gelatinase activity (1 to 10 U/mg of protein); the activity was maximal at neutral pH, was inhibited by zinc chelators, was not inhibited by tissue inhib...
متن کاملGlomerular Permeability
Ferritin was used as a tracer to investigate glomerular permeability in the nephrotic rat. The results were compared with those previously obtained in normal animals. A nephrotic syndrome was induced by 9 daily injections of the aminonucleoside of puromycin. Ferritin was administered intravenously on the 10th day, and kidney tissue was fixed at intervals of 5 minutes to 44 hours after injection...
متن کاملGlomerular Permeability
Wistar/Furth rats were made nephrotic by daily administration of amino-nucleoside of puromycin, and the ultrastructural localization of horseradish peroxidase (mol wt 40,000) in the renal glomerulus was studied from 1 min to 20 hr after intravenous injection of the tracer. In control rats, peroxidase permeated the endothelial fenestrae, the basement membrane, and the epithelial slits, and was p...
متن کاملTransdifferentiation of epithelial glomerular cells.
Cell transdifferentiation is characterized by loss of some phenotypes along with acquisition of new phenotypes in differentiated cells. Differentiated cells are endowed with the capacity of transforming into cells of a different type having other functions (1,2). Gene expression in differentiated cells has long been considered an irreversible phenomenon that is established at the time of replic...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2005
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2005050509